Rhodium-catalyzed enantioselective hydrogenation of beta-phthalimide acrylates to synthesis of beta2-amino acids.
نویسندگان
چکیده
[Structure: see text] The enantioselective hydrogenation of beta-phthalimide acrylates provides the corresponding chiral beta2-amino acids in excellent enantiomeric excess catalyzed by Rh-monophosphorus.
منابع مشابه
Enantioselective synthesis of beta2-amino acids via Rh-catalyzed asymmetric hydrogenation with BoPhoz-type ligands: important influence of an N-H proton in the ligand on the enantioselectivity.
A series of BoPhoz-type ligands were successfully applied in the rhodium-catalyzed asymmetric hydrogenation of a number of beta-substituted or unsubstituted alpha-(phthalimidomethyl)acrylates, affording good to excellent enantioselectivities. The results suggested that the presence of an N-H proton in the BoPhoz backbone could significantly improve the enantioselectivity, and ligand (Sc,Rp)-1d,...
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ورودعنوان ژورنال:
- Organic letters
دوره 8 15 شماره
صفحات -
تاریخ انتشار 2006